Method for preparing drug-linker MC-MMAF used in antibody drug conjugate and intermediates thereof

摘要

The present invention provides a method for preparing a drug-linker MC-MMAF for use in an antibody-binding drug and an intermediate thereof. The present invention improved the reaction activity of the N-terminus, effectively controlling the occurrence of the racemization reaction. By not directly using the toxin MMAF, but by using a relatively low-toxic fragment peptide, the difficulty of mass production is reduced, and the operation is simple as there is no need for reverse-phase production.