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Large-scale feasible method for the production and purification of tumor-disintegrating rat parvovirus H-1 based on isoelectric point elimination of empty particles
Large-scale feasible method for the production and purification of tumor-disintegrating rat parvovirus H-1 based on isoelectric point elimination of empty particles
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机译:基于异电点消除空粒子的肿瘤崩解大鼠Parvovirus H-1的生产和纯化的大规模可行方法
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摘要
The present invention provides a reproducible, effective and scalable process for the purification of (infectious) parvovirus H-1 particles. The purification process allows the separation of empty particles from particles containing a full genome and is compatible with large-scale H-1PV production for clinical applications.
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