SCALABLE PROCESS FOR ONCOLYTIC RAT PARVOVIRUS H-1 PRODUCTION AND PURIFICATION BASED ON ISOELECTRIC POINT-BASED ELIMINATION OF EMPTY PARTICLES

摘要

The present invention provides a reproducible, effective and scalable process for the purification of (infectious) parvovirus H-1 particles. The purification process allows the separation of empty particles from particles containing a full genome and is compatible with large-scale H-1PV production for clinical applications.