Large-scale feasible method for the production and purification of oncolytic rat parvovirus H-1 based on elimination of empty particles by isoelectric point

摘要

The present invention provides a reproducible, effective and feasible method for the purification of (infectious) parvovirus H-1 particles. The purification method allows separation of empty particles from particles containing the complete genome and is adaptable for large-scale H-1PV production for clinical applications.