首页> 外国专利> NOVEL PYRIDINYLTRIAZINE DERIVATIVE HAVING PROTEIN KINASE INHIBITORY ACTIVITY, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING, AMELIORATING, OR TREATING CANCER COMPRISING SAME

NOVEL PYRIDINYLTRIAZINE DERIVATIVE HAVING PROTEIN KINASE INHIBITORY ACTIVITY, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING, AMELIORATING, OR TREATING CANCER COMPRISING SAME

机译:具有蛋白激酶抑制活性的新型吡啶基三嗪衍生物,以及用于预防,改善或治疗包含该癌症的药物组合物

摘要

The present invention relates to: a compound selected from among a novel pyridinyltriazine derivative having protein kinase inhibitory activity, a pharmaceutically acceptable salt thereof, a hydrate thereof, or a stereoisomer thereof; a method for preparing the compound; and a pharmaceutical composition which is for preventing, alleviating, or treating cancer and comprises the compound. A novel compound according to the present invention exhibits excellent inhibitory effects against FGFR, which is a major trigger of bladder cancer, endometrial cancer, etc., point mutations thereof, and various protein kinases other than FGFR involved in signal transduction, and is thus effective as an agent for preventing and treating abnormal cell growth diseases caused by such protein kinases.
机译:本发明涉及:一种从具有蛋白激酶抑制活性的新型吡啶基三嗪衍生物中选择的化合物,其药学上可接受的盐,其水合物或其立体异构体;一种制备化合物的方法;和药物组合物,用于预防,缓解或治疗癌症并包含化合物。根据本发明的新化合物对FGFR具有优异的抑制作用,这是膀胱癌,子宫内膜癌等的主要触发,其点突变,以及除了信号转导的FGFR之外的各种蛋白激酶,因此有效作为用于预防和治疗由此类蛋白激酶引起的异常细胞生长疾病的药剂。

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