EARLY MANAGEMENT AND PREVENTION OF SEPSIS AND SEPSIS-LIKE SYNDROMES

摘要

The present invention relates to compositions and methods of treating sepsis, acute inflammatory syndromes such as systemic inflammatory response syndrome (SIRS), anthrax and severe acute respiratory syndrome coronavirus (SARS and SARS- CoV2), neo-natal acute respiratory distress syndrome (neo-natal ARDS) by PLA2 and/or metalloprotease inhibitors, in particular, in combination with antibiotics. In embodiments, the PLA2 inhibitor is varespladib, methyl varespladib, AZD2716- R,S and LY433771, the metalloprotease inhibitor is Prinomastat, Batimastat, marimastat or vorinostat.