Polypeptides derived from the extracellular portion of the trem-1 protein and capable of acting as antagonist of the trem-1 protein, compositions comprising the same and use thereof in the manufacture of medicaments for treatment of sepsis, septic shock and sepsis-like conditions

摘要

A polypeptide comprising one or more sequences derived from CDR2 or CDR3 of a TREM-1 protein, characterized by the ability to treat, ameliorate, or lessen the symptoms of conditions including sepsis, septic shock or sepsis-like conditions and IBD.