Small RNA predictors for Alzheimer's disease

摘要

The present disclosure provides methods and kits for assessing Alzheimer's disease (AD) activity in patients receiving treatment for AD or candidate treatment for AD, as well as in patients or models, including animal and cellular models. Specifically, the present disclosure is a binary predictor of disease activity and provides biomarkers (sRNA predictors) useful for detecting and/or evaluating AD disease stage, grade and progression, and prognosis and response to therapy or candidate therapy. do. Biomarkers are also useful in the context of drug discovery and clinical trials to identify candidate drug interventions (or other treatments) useful in the treatment of diseases.