Process for preparation of MK-7 type of vitamin K2

摘要

As a method for the preparation of the MK-7 type of vitamin K ₂ , according to the "1+6" synthesis strategy, hexaprenyl chains in the "all-trans" orientation are transferred to the monoprenyl derivatives of menadiol. It is characterized by connecting. According to the present invention, R ₁ is an α-sulfonyl carbanion produced in situ from a protected monoprenyl menadiol of formula (II) representing a _{C 1-3 -alkyl group, X is a halogen} Hexaprenyl halide of formula (VII) representing an atom, preferably bromine, and in which both Z'and Z" are H, or one of Z'and Z" represents H and the other is a phenylsulfonyl group -SO _{2 Ph group} And reacted in an alkylation reaction. The hexaprenyl halide of formula (VII) is obtained by coupling two triprenyl units with or without separation of an intermediate in an alkylation reaction.