A procedure for the production of a sterile salt of alkaline metal of a penicilline (Machine-translation by Google Translate, not legally binding)

摘要

Process for the production of a sterile alkali metal salt of a penicillin, comprising passing a solution of the procaine salt of penicillin dissolved in a substantially anhydrous chloroform mixture and a lower proportion of a solvent from the group consisting of formamide, methanol and ethanol through a sterilization filter and then mixing the filtered solution with a solution, similarly sterilized by filtration, of an alkali metal salt of an organic acid from the group consisting of salicylic acids and straight lower alkanoic acids, dissolved in a solvent of the group consisting of lower alkanols and lower alkanones and containing an amount of the alkali metal salt in excess of the stoichiometrically required to convert all procaine penicillin to alkali metal penicillin and containing no more than about 2% by volume of water, and then aseptically recover the precipitated salt metalalkaline and penicillin from the resulting mother liquors. (Machine-translation by Google Translate, not legally binding)