Procedure for the preparation of phenolic steroids and their etheries (Machine-translation by Google Translate, not legally binding)

摘要

Process for the preparation of phenolic steroids and their ethers, in particular 3-hydroxy-1,3,5 (10) -estratrienes, of the formula ** (See formula) ** where X represents one of the following groups ** (See formula) ** A is hydrogen, an alkyl radical of 1 to 4 carbon atoms or an alkynyl radical of 2 to 4 carbon atoms, B is hydrogen, a free or esterified hydroxyl group, whose process is characterized by the fact of undergoing treatment, by a strong acid, a beta, gamma-disubstituted derivative of 3-keto-19-nor-steroid of the formula ** (See formula) ** where X1 represents one of the following groups ** (See formula) ** A and B have the same significance as above, Z is an optionally ketalized oxo group, R1 and R2 represent a hydrogen or halogen atom or a hydroxy group, Y represents a halogen atom or a hydroxy group or R1 and Y or R2 and Y together form an epoxy nucleus and in which only one of the substituents R1 and R2 always represents hydrogen while the other is different from hydrogen, the substituents R1, R2 and Y being both alpha and beta, and by conducting said acid treatment in solution in an inert, non-alcoholic organic solvent. (Machine-translation by Google Translate, not legally binding)