Procedure for the preparation of N- (4- (beta-3-methyl-benzamidoetil) -bencenosulfonil) -n'-ciclohexil-urea. (Machine-translation by Google Translate, not legally binding)

摘要

A process for the preparation of N- [4- (beta-3-methyl-benzamido-ethyl) -benzenesulfonyl] -N'-cyclohexylurea of the formula ** (See formula) ** or its salts, characterized by a) cyclohexylamine or optionally its salts are reacted with 4- (beta-3-methyl-benzamido-ethyl) -benzenesulfonyl isocyanate, sulfonyl, esters of 4- (beta-3-methyl-benzamido-ethyl) - benzenesulfonylcarbamic acid, esters of 4- (beta-3-methyl-benzamido-ethyl) -benzenesulfonylthiocarbamic acid, 4- (beta-3-methyl-benzamido-ethyl) -benzenesulfonylcarbamic acid halides or 4- (beta-3-methyl-benzamido) -ethyl) -benzene-sulfonylurea. b) 4- (beta-3-methyl-benzamido-ethyl) -benzenesulfonamide or its salts are reacted with cyclohexyl isocyanate, cyclohexylcarbamic acid esters, cyclohexylthiocarbamic acid esters, cyclohexylcarbamic acid halides or cyclohexylureas, c) 4- (beta-3-methyl-benzamido-ethyl) -benzenesulfonyl chloride is reacted with cyclohexylurea, cyclohexylisourea ethers, cyclohexyl isothiourea ethers or cyclohexylparabenic acids and the benzenesulfonyl isurene ethers, benzenesulfonyl isothiourea ethers or acids are hydrolysed benzenesulfonylparaban, obtained from this or otherwise. d) in N- [4- (beta-3-methyl-benzamido-ethyl) -benzenesulfonyl] -N'-cyclohexyl thiourea, the sulfur atom is replaced by an oxygen atom. e) N- [4- (beta-3-methyl-benzamido-ethyl) -benzenesulfenyl] -N'-cyclohexyl-urea or the corresponding benzenesulfinyl urea is oxidized. f) benzoyl N- [4- (beta-3-methyl-amino-ethyl) -benzenesulfonyl] -N'-cyclohexylurea. and optionally, the products of the process are treated with alkaline agents for the formation of salts. (Machine-translation by Google Translate, not legally binding)