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process for the preparation of a bismuth containing substance for use against inflammation and ulceration in the digestive system and method for the preparation of a pharmaceutical preparationthe basis of the obtained bismuth containing substance.
process for the preparation of a bismuth containing substance for use against inflammation and ulceration in the digestive system and method for the preparation of a pharmaceutical preparationthe basis of the obtained bismuth containing substance.
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机译:用于在消化系统中对抗炎症和溃疡的含铋物质的制备方法以及制备该含铋物质的药物制剂的方法。
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摘要
A pharmaceutical composition for treating inflammation and infections of the stomach and intestines contains at least one water-sol. protein-type bismuth complex which is reversibly precipitable with alcohol and in which the bismuth is bonded so as to be stable towards dialysis. The protein type material is selected from the globular proteins and these are chemically modified or at least partially denatured and/or degraded in such way that new nucleophile positions in the protein molecule molecule are set free and these are at least partially taken by bismuth. The protein-type material has an isoelectric point adapted to the ambience of the tissue to be treated; it may be chemically modified pepsin, or trypsin or chymotrypsin. The complex is prepd. by reacting a water-sol. protein-type material with a sol. bismuth cpd.; complex formation takes place while the protein material is subjected to chemical modification by gradual heating, pref. in alkaline medium.
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