Water-soluble complexes of bismuth and polyacrylates, preparation methods thereof, and pharmaceutical compositions for treating ulcerative colitis containing the complexes or other bismuth salts

摘要

The present invention relates to complexes of bismuth (eg bismuth salts) with polyacrylates (eg carbomers) which can be incorporated into pharmaceutical compositions for oral administration, oral sustained release administration and rectal administration. The complex may be combined with an antibiotic such as tetracycline and an antiprotozoal agent such as metronidazole for use in the treatment of infection by Helicobacter pyroller. Also described are methods for treating inflammatory bowel disease using bismuth / polyacrylate complexes or other bismuth preparations.