Syntheses, Crystal Structures and Anticancer Activities of Dithiocarbamate Bismuth(Ⅲ) Complexes

摘要

Two novel complexes, [Bi(III)(S2CNBn Et)3] 1 and [Bi(III)(S2CNPPPy-2)3] 2, were synthesized and characterized by elemental analysis, IR, 1H NMR, 13 C NMR, TG-DTG and X-ray single-crystal diffraction. The structure reveals that complex 1 belongs to the monoclinic system, space group P21/c with a = 11.457(5), b = 17.437(8), c = 33.439(14), β= 98.499(8)o, Z = 4, V = 6607(5)3, Dc = 1.689 g·cm-3, F(000) = 3328, μ= 5.742 mm-1, the final R = 0.0906, w R = 0.1678 and S = 1.032. The structure indicates that complex 2 belongs to the triclinic system, space group P1 with a = 12.608(9), b = 12.622(8), c = 12.49(6), α = 102.652(15), β = 103.013(14), γ = 109.698(10)o, Z = 1, V = 1762.3(19)3, Dc = 1.741 g·cm-3, F(000) = 916, μ = 5.395 mm-1, the final R = 0.048 2, w R = 0.1206 and S =1.046. In the two complexes, each six-coordinated Bi(III) atom adopts a pentagonal pyramidal configuration with six sulfur atoms from three ligands, and the dimmer structures are formed by weak interactions of Bi···S between two molecules. The anticancer activities of the two complexes were studied by evaluating their cytotoxicities against several human cancer cell lines using the MTT assay. Results indicated complex 2 showed moderate cytotoxic effects on the selected cancer cells.