A method for the production of 5 - fluorouracil - riboside and 6 - mercaptopurine - riboside

摘要

1,148,058. Production of nucleosides by fermentation. KYOWA HAKKO KOGYO CO Ltd. 14 July, 1966 [19 July, 1965], No. 31709/66. Heading C2C. 5-Fluorouracil riboside or 6-mercaptopurine riboside are obtained by culturing a microorganism beloning to Bacillus subtilis or Streptomyces fradiae in an aqueous nutrient medium containing a carbon source, a nitrogen source and inorganic salts, under aerobic conditions in the presence of a base which is 5-fluorouracil in the case of the production of 5-fluorouracil riboside, and 6-mercaptopurine in the case of the production of 6-mercaptopurine riboside. The culturing is preferably carried out at a temperature of 20-40‹ C. and a pH of 5-9.