A procedure for the preparation of new derivatives of homopirimidazol. (Machine-translation by Google Translate, not legally binding)

摘要

A procedure for the preparation of new homopyrimidazole derivatives of the general formula **(See formula)** where R, R1, R2 and R3 represent hydrogen, alcohol, halogen, alkoxy, nitro or amino; R4 is hydrogen, alcohol, aralcohyl, aryl, = 0, alkoxy, halogen or hydroxyl; R5 is hydrogen, halogen or a group -COOH, -COO-alcoholic, -CONH2, -CORH-alcoholic, -CON (alcoholic) 2, -CH2OH, -CH2O-alcoholic or -CO-nhoh; R6 is hydrogen, alcohol, aralcohyl, aryl, = 0, alkoxy, halogen or hydroxyl; R7 is hydrogen, alcoholic, aryl or aralcohyl; and the dashed lines represent optional double bonds, which comprises reacting an amino-pyridine derivative of the general formula. **(See formula)** wherein the substituents R, R1, R2 and R3 have the same meanings as indicated above, with a compound of the general formula **(See formula)** wherein R8 is hydrogen, alcoholic, aralkoxy, aryl, = 0, alkoxy, halogen, or hydroxyl; R9 is hydrogen, alcohol, aralcohyl, aryl, halogen, a radical of a carboxylic acid or of a carboxylic acid derivative; R10 is hydrogen, alcohol, aralcohyl, aryl, = 0, alkoxy, halogen, or hydroxyl; R11 is alkoxy, = 0, hydroxyl, hydrogen or halogen; R12 is alkoxy, = 0, hydroxyl, hydrogen or halogen, and cyclize the condensation product thus obtained, if desired, after isolation, in the presence of phosphoric acid and an acidic condensation agent, whereby compounds of the general formula **(See formula)** or salts thereof (in which the R-R10 substituents have the same meanings as indicated above) and, if desired, convert the compounds thus obtained into their salts, or release the bases from their salts, or convert one salt in another, and/or, if desired, reducing a compound thus obtained, or introducing substituents R4, R5, R6 and/or R7 into the molecule, by methods known per se. (Machine-translation by Google Translate, not legally binding)