1304645 Substituted indoles ROUSSEL UCLAF 8 July 1971 [8 July 1970] 32187/71 Heading C2C The invention comprises compounds of formula wherein Y, Z are each H, halogen, C 1-6 alkoxy, di(C 1-6 -alkyl)amino, C 1-5 alkyl, NO 2 , CF 3 , C 1-6 alkylthio (possibly aryl-substituted), or C 1-6 alkylsulphonyl; Ar, which is optionally substituted, is cyclohexyl or a homocyclic or heterocyclic aromatic group; A is CHRSP1/SP (where RSP1/SP is H or C 1-6 alkyl; and R, RSP1/SP are either both H(Ia), or together form a di(C 1-6 -alkyl)methylene group (Ib). Ia are prepared by acid hydrolysis of Ib; Ib are prepared by reacting (i) under basic conditions, a 1-unsubstituted indole with a 4 - (haloalkanoyloxymethyl) - 1,3 - dioxolan, or (ii) a 1-alkoxycarbonylalkyl-indole with a 4-hydroxymethyl -1,3 -dioxolan. Therapeutic compositions for oral, parenteral, permucous rectal or topical administration comprise compounds of the above formula, which have analgesic and anti-inflammatory properties. Besides a carrier or excipient, there may be present a spasmolytic, hypnotic, anticoagulant or agent improving diffusion in the organism and/or penetration of the tissues of the above compounds.
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