Ampicillin-guaiacolsulfonic acid prodn - by reacting guaiacolsulphonic acid with ampicillin trihydrate

摘要

Title cpds. of formula (I) is prepd. by reacting guaiacolsulphonic acid with ampicillin trihydrate in water or 1-3C alcohol at a temp. of 5 degrees C. The product has an ampicillin activity and can be administered in the form of injection liquid because it is very soluble in water. Also, it has a higher stability than the sodium salt of ampicillin when it is stored under dry conditions.