Procedure for the production of 5-phenyl-1, 3, 4, 4a, 5, 9b-hexahidro-2H-indeno (1,2-c) pyridines. (Machine-translation by Google Translate, not legally binding)

摘要

Process for the production of 5-phenyl-1,3,4,4a, 5,9b-hexahydro-2H-indene [1,2-c] pyridines, of formula Id, **(See formula)** wherein RIII1 signifies hydrogen or a lower alkyl radical, R2 signifies chlorine, bromine, fluorine, or a lower alkyl radical, and signifies hydrogen, chlorine, bromine, fluorine, an alkyl, alkylthio or lower alkoxy radical, or trifluoromethyl, characterized in that a compound is reduced in which the 4a/5 hydrogen atoms are trans and the 4a/9b hydrogen atoms are trans, or in which the 4a/5 hydrogen atoms are trans and the 4a/9b hydrogen atoms are cis, respectively, of formula Ie, **(See formula)** wherein RIV1 signifies hydrogen, a lower alkyl or alkoxy radical, and R2 and R3 have the above meanings, with lithium aluminum hydride, aluminum hydride or diborane, in a solvent that is inert under the reaction conditions, and where necessary, mixtures of compounds are separated where the 4a/5 hydrogen atoms are trans and the 4a/9b hydrogen atoms are trans, and where the 4a/5 hydrogen atoms are trans and the Hydrogen 4a/9b are cis, in order to isolate one isomer or each of the isomers. (Machine-translation by Google Translate, not legally binding)