1,2,3,4,5,6-Hexahydro-3-(3-methyl-2-butenyl)-6-methyl-11(EQ)- hydroxy-11- meth yl-2,6-methano-3-benzazocine

摘要

11-Oxygenated-2,6-methano-3-benzazocines N-alkylated by alkylmethyl, haloalkenylmethyl, alkynylmethyl, cycloalkylmethyl, cycloalkenylmethyl, cycloalkyl or 2-cycloalkenyl are prepared directly by N-alkylation of the corresponding N-H intermediates or indirectly by N- acylation of the corresponding N-H intermediates followed by reduction of the resulting N- acylated intermediates and are useful as antagonists of narcotic analgesics.