Procedure for obtaining a penicilline ester. (Machine-translation by Google Translate, not legally binding)

摘要

The present invention relates to a process for obtaining a penicillin ester of formula i: ** (formula) ** and its non-toxic addition salts, compounds which are characterized by their properties as broad spectrum antibiotics. The 6- (2-hydroxy-benzylideneamino) -3,3-dimethyl-7-oco-4-thia-l-azabicide [3.2.0] heptane-2-carboxylic acid is reacted, preferably in the form of salt with a tertiary amine, with 3-bromophthalide in an inert and rigorously dry medium, thus obtaining 6- (2-hydroxy-benzylideneamino) -3,3-dimethyl-7-oxo-4-thia-1-azabicyclo [3.2.0] heptane-2-carboxylate of 3-hydroxyphthalide. (Machine-translation by Google Translate, not legally binding)