Process for the preparation of 2,4-diamino -5-(3',4',5'-trimethoxybenzyl)pyrimidine intended as a potentiator for sulphacetamide contained in pharmaceutical preparations in addition to polymixin

摘要

2,4-Diamino-5-(3',4',5'-trimethoxybenzyl)pyrimidine, which is intended as a potentiator for sulphacetamide contained in a pharmaceutical preparation for administration to the eye or to the ear, which additionally contains polymixin in the form of a pharmaceutically acceptable salt, is prepared by reacting an appropriately substituted beta -aminoalpha -benzylacrylonitrile of the accompanying formula, in which Z denotes an aliphatic, aromatic or heterocyclic amino group -NR'R'', where R' or R'' can also denote hydrogen, with guanidine. IMAGE