The First Metal Complexes of 46-diamino-1-hydro-5-hydroxy-pyrimidine-2-thione: Preparation Physical and Spectroscopic Studies and Preliminary Antimicrobial Properties

摘要

The new complexes [M2O5L2(H2O)2] · H2O (M = Mo, >1; M = W, >2), [RuL2(H2O)2] · H2O >(3), [ML3] · xH2O (M = Rh, x = 2, >4; M = Ir, x = 1, >5), [RhL2(PPh3)2](ClO4) · 2H₂O >(6), [PdL₂] · 2H₂O >(7), [PdL(phen)]Cl · H₂O >(8), [Re OL₂(PPh₃)]Cl >(9) and [UO₂L₂] >(10) are reported, where LH is 4,6-diamino-1-hydro-5-hydroxy-pyrimidine-2-thione. The complexes were characterized by elemental analyses, physical techniques (molar conductivity, room-temperature magnetic susceptibility), and spectroscopic (IR, Raman, UV/VIS/ligand field, NMR, mass) methods. The ligand L⁻ is in its thione form and behaves as a bidentate chelate with the deprotonated (hydroxyl) oxygen and the nitrogen of one amino group as donor atoms. Oxobridged dinuclear >(1, 2) and various mononuclear >(3–10) structures are assigned for the complexes in the solid state. The metal ion coordination geometries are octahedral >(1–6, 9, 10) or square planar >(7, 8). The free ligand LH and complexes >1, >4, >7, and >8 were assayed in vitro for antimicrobial activity against two bacterial and two fungal cultures.