4-SUBSTITUTED 2-AMINOTHIAZOLCARBOXYLIC ACIDS AND DERIVATIVES THEREOF USED AS ADDITIVES TO HERBICIDES TO LIMIT EFFECTS ON HUMAN PLANTS

摘要

2-amino-4-substituted-5-thiazolecarboxylic acids and derivatives thereof, are intermediates for the preparation of 2-substituted-4-substituted-5-thiazolecarboxylic acid derivatives which are herbicidal safeners. The compounds of the invention have the formula …CHEM… wherein n is zero or one; R is alkyl having 3 to 9 carbon atoms, cycloalkyl having 3 to 8 carbon atoms, nalo (lower) alkyl, or …CHEM… wherein… X and Y independently equal hydrogen, halogen, trifluoromethyl or lower alkyl; when n is one R1 is hydrogen, alkyl having 1 to 10 carbon atoms, lower alkenyl, lower alkynyl, lower alkoxy lower alkyl, halo(lower)alkyl, benzyl, phenyl or phenyl substituted by one to two halogen, lower alkyl or trifluoromemoieties; when n is zero R1 is -NR2R3 where R2 and R3 independently equal lower alkyl; provided that when n is one and R1 is hydrogen, X and Y cannot both equal hydrogen; further provided that when n is one and R1 is alkyl containing 1 to 10 carbon atoms or benzyl, R cannot equal trifluormethyl.