PROCESS FOR THE PREPARATION OF 10,19-DIHYDRO-VITAMIN D DERIVATIVES AND SOME NOVEL 10,19-DIHYDRO-1ALPHA-HYDROXY AND 1 ALPHA,25-DIHYDROXY-VITAMIN D3 COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

摘要

A process for the preparation of 5,6-cis- and 5,6-trans-10,19-dihydro-vitamin D derivatives which comprises hydrogenating a corresponding vitamin D compound in the presence of a ligand-coordinated homogeneous transition metal catalyst whereby the C-19 methylene group of the vitamin D compound is converted into a methyl group.