BICYCLO (3.1.0) HEXYL-SUBSTITUTED CABONYLAMINOPHENOXY CARDIOVASCULAR

摘要

Bicyclo[3.1.0] hexyl-substituted carbonylaminophenoxy compounds of the formula …CHEM… where R is i-propyl or t-butyl; R2 is H, halo, CN, C1-2 alkyl, C1-2 alkoxy, acetyl or propionyl; Y is NR5 where R5 is H or methyl; n is 0 or 1 and m is 1 or 2; and their pharmaceutically acceptable salts; and pharmaceutical compositions containing such compounds, can be used for treating cardiac disorders, hypertension and glaucoma in mammals, and may have local anesthetic properties. They can be prepared by reaction of isopropylamine or t-butylamine with the corresponding compound having …CHEM… in place of -OCH2CH(OH)CH2NHR, or by hydrolysing the corresponding compound having …CHEM… in place of -OCH2CH(OH)CH2NHR, in which R3 is H, alkyl or optionally substituted carbocyclic aryl.