Process for the preparation of 1-oxa-beta-lactam antibiotics

摘要

Bicyclic 1-oxa- beta -lactam diacid antibiotics represented by the formula IMAGE wherein R is phenyl, hydroxyphenyl, acetoxyphenyl, alkylphenyl, or halophenyl, thienyl or furyl; R DEG is H or OCH3; and the pharmaceutically acceptable non-toxic salts thereof are broad spectrum antibiotics useful for controlling infections in man and animals. The compounds are prepared by reacting the corresponding 3-halomethyl diester with 1-cyanomethyl-1H-tetrazole -5-thiol followed by deesterification.