A series of novel 3-amino-5-(4-pyridyl)-1,2,4-triazole derivatives has been prepared, including their pharmaceutically acceptable acid addition salts. These particular compounds are useful in therapy as anti-ulcer agents. Preferred member compounds include 3-amino-5-[2-(N-monomethylamino)-4-pyridyl]-1,2,4-triazole, 3-amino-5-[2-(N-monoethylamino)-4-pyridyl]-1,2,4-triazole and 3-amino-5-[2-(N,N-dimethylamino)-4-pyridyl]-1,2,4-triazole. Alternate methods of preparation are provided and the principal synthetic routes leading to the preferred compounds are described in some detail.
展开▼
