首页> 外国专利> Method for preparing 3 - (3 - amino - 1 (4H - 5.6 - Di - (b) hidrociclopenta propanoles tieniloxi) - 2 - and 3 - amino - 1 - (3 - ((b) - tetrahidrobenzo also tieniloxi) - 2 and - propanoles) for which any of its Salts

Method for preparing 3 - (3 - amino - 1 (4H - 5.6 - Di - (b) hidrociclopenta propanoles tieniloxi) - 2 - and 3 - amino - 1 - (3 - ((b) - tetrahidrobenzo also tieniloxi) - 2 and - propanoles) for which any of its Salts

机译:制备3-(3-氨基-1(4H-5.6-二-(b)广lop丙醇蒂尼洛西)-2-和3-氨基-1-(3-((b)-四氢苯并也蒂尼洛西)-2和-丙醇盐)

摘要

Procedure for the synthesis of 3 - amino - 1 - (3 - 4 - 5 - dihidrociclopenta (b) tieniloxi propanoles) - 2 - and 3 - amino - 1 - (3 - ((b) - tetrahidrobenzo also tieniloxi) - 2 - propanoles, as well as its Salts of formula (i), the R is alkyl, and N is ariloxialquilo aralquilo or 3 to 5.Involves the reaction of a compound of formula (ii), in which n is 3 - 5 with a hepiclorhidrina in the presence of a base and a Solvent aprotico, followed by reaction with an Amine of the formula R - NH2, where r is the same as in formula (i), warming with an aqueous solution Sodium hydroxide in the presence of ethanol, Acidification with hydrochloric acid.
机译:合成3-氨基-1-(3-4-5-二hidrociclopenta(b)替尼洛西丙醇)-2-和3-氨基-1-(3-((b)-四氢苯并也替尼洛西)-2-丙醇及其式(i)的盐,R为烷基,N为ariloxialquilo aralquilo或3至5。涉及其中n为3-5的式(ii)化合物与庚啶的反应在碱和溶剂非质子存在下,然后与式R-NH2的胺反应,其中r与式(i)相同,在乙醇存在下用氢氧化钠水溶液加热,酸化用盐酸。

著录项

  • 公开/公告号ES8204433A1

    专利类型

  • 公开/公告日1982-08-01

    原文格式PDF

  • 申请/专利权人 CONSEJO SUPERIOR INVESTIGACIONES CIENTIFICAS;

    申请/专利号ES19810504407

  • 发明设计人

    申请日1981-07-29

  • 分类号C07D333/64;A61K31/38;C07D333/78;C07D333/80;

  • 国家 ES

  • 入库时间 2022-08-22 13:19:43

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