process for the manufacture of trans - delta2 prostaglandin d derivatives

摘要

Trans- DELTA 2-prostaglandin D derivatives of the formula: IMAGE (I) wherein [A] is a group of the formula: IMAGE X is ethylene or cis-vinylene, C13-C14-C15 is: (i) a group of the formula: IMAGE (V) when [A] is a group of the formula (II) or (III), or (ii) a group of the formula: IMAGE (VI) when [A] is a group of the formula (IV), R is hydrogen or alkyl, R1 is a single bond or alkylene, R2 is alkyl, cycloalkyl, phenyl or phenoxy, the double bonds between C2-C3 and between C13-C14 are both E, the double bond between C9-C10 is Z and the double bonds between C12-C13 and between C14-C15 are E, Z or a mixture thereof, provided that when R1 is a single bond, R2 does not represent a substituted or unsubstituted phenoxy group, and cyclodextrin clathrates and non-toxic salts thereof, possess anti-tumor activity.