'Procedure for the preparation of New 1,4,9,10 - tetrahydro - pyrazolo (4.3 - e) pirido (3,2-b) (1,4) - 10 - diazepin Onas'.

摘要

Procedure for obtaining 1,4,9,10 pyrazolo - tetrahydro - 4.3 - e - B pirido 3.2 1.4 diazepin - 10 - onas, of formula (i) in which R is Hydrogen or alcohilo - C C - is alcohilo; R; R is Hydrogen or alcohilo C -; and R is Hydrogen or alcohilo C -.Consists in the cyclization reaction of N - (2 - halogen - 3-pyridinyl) - 4 - amino - 5 - 1H pyrazole carboxamide, of formula (ii), in which R - R have the same meaning as in formula (i), and Hal is a Halogen Atom. The reaction is performed in an Inert Organic Solvent, possibly in the presence of a Mineral acid as a catalyst at a temperature between 80 and 200 V. CThese compounds have pharmacological applications for its Analgesic, antiphlogistic and antipyretic.