IMPROVEMENTS IN AND RELATING TO SUBSTITUTED TETRAHYDRONAPHTHALENES

摘要

Dl-1-(or 3-) carbamoyl-2-hydroxy-5,6,7,8- tetrahydronaphthalenes of the formula …CHEM… wherein:… one of R and R1 is H and the other is CONH2,… R2 and R3 are individually H, methyl, ethyl or n-propyl, and… pharmaceutically-acceptable acid addition salts thereof. …??The compounds are prepared by amidating the 1-(or 3-)ester or carboxhydrizide by reducing the 6-azide, by cleaving the 2-benzyl-oxy group, or by alkylating the 6-amine. …??These compounds possess a dopamine- like pharmacological activity.