PERCUTANEOUS ADMINISTRATION OF PHYSIOLOGICAL ACTIVATOR USING ADJUVANT, SOLVENT AND DIOL MODULATOR

摘要

PURPOSE:To raise permeability and percutaneous absorption of physiological activator, by using a multi-component carrier system consisting of at least adjuvant (component A), at least one solvent (component B), and at least one diol modulator. CONSTITUTION:The component A of at least one (5-24C straight-chain, branched or cyclic aliphatic hydrocarbon, 5-24C straight-chain, branched or cyclic aliphatic hydorcarbon replaced with one or more halogens, alcohol ester of 7- 18C aliphatic carboxylic acid) is blended with the component B of at least one I [thioglycerol, lactic acid or its ester, cyclic urea, compound shown by the formula I (R1-R4 are H, 1-4C lower alkyl, or 1-2C acyl), compound shown by the formula II (R5 is H, or 1-4C lower alkyl; n is 3-5), etc.] and a diol modulator, and the blend is mixed with a physiological activator, and applied to the skin. The diol mudulator reduces activity of the components A and B, and further controls the rate of absorption of the activator.