PHARMACEUTICAL COMPOSITIONS COMPRISING TRIMETHOPRIM AND ONE OR MORE N-ETHYL-YPSILON-PYRIDONE-3-CARBOXYLIC ACID DERIVATIVES

摘要

Pharmaceutical compositions comprising trimethoprim and a N-ethyl- gamma -pyridone-3-carboxylic acid derivative, such as nalidixic, oxolinic or piromidic acid, are more effective than previously known trimethoprim-containing compositions for the treatment of infections affecting the urinary tract. Trimethoprim and the foregoing acid derivatives unpredictably show a noticeable synergistic effect.