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Compounds and compositions for inhibiting estrogen sulfotransferase transferase activity, process and novel intermediates therein
Compounds and compositions for inhibiting estrogen sulfotransferase transferase activity, process and novel intermediates therein
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机译:抑制雌激素磺基转移酶转移酶活性的化合物和组合物,方法以及其中的新型中间体
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摘要
The present invention concerns the novel compounds having fluoro, amino, nitro or hydroxy monosubstituted at the 2- or 4- position on deoxyestrone as well as deoxyestra-17-ol. The compounds are useful as estrogen sulfotransferase inhibitors. Such estrogen sulfotransferase inhibition provides the novel use for treating a female mammal to prevent implantation of a blastocyst. Additionally, the invention concerns the novel synthesis and novel intermediates in the synthesis of the estrogen sulfotransferase inhibiting compound of the present invention.
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