Polymorphisms in sulfotransferase 1A1 and glutathione 5-transferase P1 genes in relation to colorectal cancer risk and patients' survival

摘要

AIM: To examine whether polymorphisms in SULT1A1 and GSTP1 genes contribute to colorectal cancer development and whether they are associated with clinicopathological variables are not well identified.METHODS: We examined the genotypes of 125colorectal cancer patients and 666 healthy controls in a Swedish population by using PCR-restriction fragment length polymorphism (RFLP).RESULTS: SULT1A1*2/*2 genotype (OR=2.49,95%CI=1.48-4.19, P=0.0002) and *2 allele (OR=1.56, 95%CI = 1.16-2.10, P = 0.002) had an effect on colorectal cancer susceptibility, while GSTP1 genotype was without effect. However, GSTP1 G-type predicted a worse prognosis in the patients independently of gender,age, Dukes'stage, growth pattern, and differentiation (P=0.03).CONCLUSION: Polymorphism in SULT1A1 may predispose to colorectal cancer and GSTP1 may be a biological indicator of prognosis in the patients.