Polypeptides of formula (I) including salts and complexes are new: In (I) either (a) A = A1-W-A2-CO-N(A3)-CH(Z)-CO; W = CO-N(A4)- or -N(A5)-CO-; A1 and A4 each = H, (un)satd. hydrocarbyl or 7-10C phenylalkyl in which phenyl is opt. substd.; A5 = H or (un)satd. hydrocarbyl; or A1+A5 = tetra-or pentamethylene; A2 (un)satd. alkylene; A3 = an A4 gp.; N-CH(Z)-CO = (1) an (L)- or (D)- Phe residue opt. ring substd. or (2) the residue of a natural alpha-amino acid other than (1) or of a corresp. (D)-aminoacid; Z in N-CH(Z)-CO-represents the remainder of residue (1) or (2); A' = H; and Y1 and Y2 each = H or together represent a bond; or (b) A = H, alkyl, phenylalkyl or RCO; R = H, alkyl, phenyl or phenylalkyl; or RCO = (1), (2) or (3) a dipeptide residue in which the individual aminoacid residues are the same or different (1) or (2), the alpha-amino gp. of aminoacid residues (1) and (2) or the N-terminal amino gp. of dipeptide residues (3) opt. substd. by alkyl or 7-10C phenylalkyl and/or acyl; A' = H or when A is alkyl or phenylalkyl, then A' can also be 1-12C alkyl; Y1 and Y2 each = CO-CRaRb-(CH2)m-H, CO-NHRc, CO-NH-CHRd-COORe or a gp. of formula (4) or (5): Ra = Me or Et; Rb = H, Me or Et; m = 1-4; n = 1-5; Rc = 1-6C alkyl; Rd = the substit. attaching to the alpha-C of a neutral alpha-aminoacid (including H); R'a and R'b each = H, Me or Et; R8 and R9 = H, halo, 1-3C alkyl or 1-3C alkoxy; p = 0 or 1; q = 0 or 1; r = 0-2; and for both cases (a) and (b): B = Phe opt. ring-substd.; C' = (L)-Trp or (D) Trp, opt. alpha-N-methylated and opt. benzene-ring substd.; D = Lys opt. alpha-N-methylated; E = Thr, Ser or Val; F = COOR1, CH2OR2, CONR3R4 or gp. (6): R1 = H or 1-3C alkyl; R2 = H or the residue of hydrolysable ester; R3 = H, alkyl, phenyl or phenylalkyl; R4 = H, 1-3C alkyl or CH(R5)X; R5 = H, (CH2)2-OH or (CH2)3-OH or Rd; X = COOR1, CH2OR2 or CONR6R7; R6 = H or 1-3C alkyl; R7 = H, 1-3C alkyl, phenyl or 7-10C phenylalkyl. (50pp).
展开▼
