A process for producing 2,6 Dimethyl 4 (3nitrofenil) - 3.5 - dicarboxilato dihidropiridin - 1.4 - 1, 3 - Methyl and benzyl - piperidilo and its hydrochloride.

摘要

Process for producing 2,6 Dimethyl 4 - (3-nitrophenyl) - 1.4 - dihidropiridin - 3.5 - dicarboxilato 1 - Benzyl - 3 - Methyl piperidilo and its hydrochloride.Involves reacting a compound of formula (ii) or a reactive Derivative of the alcohol with a formula (iii) in a molar ratio of 1 / 8 to 1 / 2, respectively, at a temperature of c70jc to 100jc, in the presence of an Inert Solvent such as acetonitrile and a Polar atropico Agent Co. Ndensante to obtain a compound of formula (i),Its hydrochloride and its Optical isomers or their mixture racimica hydrochloride, which has a melting point of 202jc 196. The Optical isomers and the racemate can be separated by Chromatography or salts derived cristalizacion.se used in treatment of cardiovascular diseases.