Procedure for obtaining a compound Peptide to antagonize the in vivo Response of an animal to the Antidiuretic Action of ADH.

摘要

Procedure for obtaining a compound Peptide to antagonize the in vivo Response of an animal to the Antidiuretic Action of ADH.Consists of: (a) treat by Solid Phase Synthesis of BOC Gly Resin and Neutralization and coupling with an amino acid to produce BOC PHE Val ASN CY (Bzl) - W (d or L - (coughing) - Arg - Gly - Resin); (b) addressing the previous composite in a cycle of Vulnerability,Neutralize with BOC and attach x to produce TERT butoxycarbonyl (BOC octapeptidil Resin Formula X - Phe Val ASN CY (Bzl) - w or L D -) (coughing) Arg Gly resin); (c) amonolizar Compound obtained in (b) to produce a compound of formula Boc - xphe Val ASN CY (Bzl) - W - (D - or L - (coughing) - Arg - Gly - NH2); (d) conve As the compound obtained in (c) a compound of formula (ii); and (e) convert the compound (d)A Peptide of formula (i).