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Human placental angiogenic factor, which is able to stimulate the synthesis of papillary endothelial cell protease, DNA synthesis and migration
Human placental angiogenic factor, which is able to stimulate the synthesis of papillary endothelial cell protease, DNA synthesis and migration
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机译:人胎盘血管生成因子,能够刺激乳头状内皮细胞蛋白酶的合成,DNA的合成和迁移
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摘要
An angiogenic factor is disclosed which is a purified, single-polypeptide-chain protein having at least one active site possessing an activity selected from the group consisting of mitogenic activity, chemotactic activity, the ability to stimulate protease synthesis and combinations thereof. This angiogenic factor exhibits substantial homology to and is immunologically equivalent to the native angiogenic factor isolatable from human placental tissues. The amino acid sequence of this angiogenic factor is also disclosed. In addition, a method for isolation of the purified angiogenic factor from human placental tissues is set forth. Pharmaceutical preparations incorporating this angiogenic factor are described.
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