Development of micropatterned hydrogels immobilized with a basic fibroblast growth factor (bFGF) for modulation of angiogenic responses of human umbilical vein endothelial cells

摘要

In this study, we prepared biomimetic hydrogels conjugated with RGD peptide and bFGF with enzyme triggered method. Furthermore, we fabricated anisotropic micro-patterned hydrogel to promote the vascularization of endothelial cells. Our results suggest that, these hydrogels with incorporated bFGF and micropattern grooves can be potentially utilized as a bioactive substrate to regulate HUVEC behaviors.