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METHOD FOR THE PRODUCTION OF ANGIOGENIC FACTOR OF HUMAN PLACENTA ABLE TO STIMULATE THE SYNTHESIS OF PROTEASES, DNA AND MIGRATION SYNTHESIS OF HAIR ENDOTHELIAL CELLS
METHOD FOR THE PRODUCTION OF ANGIOGENIC FACTOR OF HUMAN PLACENTA ABLE TO STIMULATE THE SYNTHESIS OF PROTEASES, DNA AND MIGRATION SYNTHESIS OF HAIR ENDOTHELIAL CELLS
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机译:能够刺激蛋白酶,DNA合成和毛发内皮细胞迁移合成的人类胎盘血管生成因子的制备方法
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摘要
An angiogenic factor is disclosed which is a purified, single-polypeptide-chain protein having at least one active site possessing an activity selected from the group consisting of mitogenic activity, chemotactic activity, the ability to stimulate protease synthesis and combinations thereof. This angiogenic factor exhibits substantial homology to and is immunologically equivalent to the native angiogenic factor isolatable from human placental tissues. The amino acid sequence of this angiogenic factor is also disclosed. In addition, a method for isolation of the purified angiogenic factor from human placental tissues is set forth. Pharmaceutical preparations incorporating this angiogenic factor are described.
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