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HUMAN PLACENTA ANGIOGENIC FACTOR CAPABLE OF STIMULATING CAPILLARY ENDOTHELIAL CELL PROTEASE SYNTHESIS, DNA SYNTHESIS AND MIGRATION
HUMAN PLACENTA ANGIOGENIC FACTOR CAPABLE OF STIMULATING CAPILLARY ENDOTHELIAL CELL PROTEASE SYNTHESIS, DNA SYNTHESIS AND MIGRATION
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机译:刺激毛细血管内皮细胞蛋白酶合成,DNA合成和迁移的人类胎盘血管生成因子
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摘要
An angiogenic factor is disclosed which is a purified, single-polypeptide-chain protein having at least one active site possessing an activity selected from the group consisting of mitogenic activity, chemotactic activity, the ability to stimulate protease synthesis and combinations thereof. This angiogenic factor exhibits substantial homology to and is immunologically equivalent to the native angiogenic factor isolatable from human placental tissues. The amino acid sequence of this angiogenic factor is also disclosed. In addition, a method for isolation of the purified angiogenic factor from human placental tissues is set forth. Pharmaceutical preparations incorporating this angiogenic factor are described.
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