A PROCEDURE FOR THE PREPARATION OF ACTIVATED ELECTROPHILIC KETONE DERIVATIVES OF PEPTIDASE SUBSTRATES, USEFUL IN THE INHIBITION OF PROTEASE ENZYMES

摘要

This invention relates to analogs of peptidase substrates in which the amide group containing the scissile amide bond of the substrate peptide has been replaced by an activated electrophilic ketone moiety. These analogs of the peptidase substrates provide specific enzyme inhibitors for a variety of proteases, the inhibition of which will have useful physiological consequences in a variety of disease states.