A process for preparing ketone Derivatives of electrophilic Substrates activated peptidase, useful in the inhibition of Enzymes proteases

摘要

Process for preparing ketone Derivatives of electrophilic Substrates activated peptidase. To copulate with a compound of formula (r5y) with a compound of formula (ii) in chloroform, and 60gc 0g and during 0.5 to 48 hours to obtain a compound of formula (i).R2 and R4 Side Chains being: group R (iii); R3, 1 to 4 h, alkyl C and linear or branched OTRIs; (iii); R5 and R6, phenyl or benzyl; - nhr3 or OR3 and (iii) building blocks of Alpha Amino Acids selected from (a) (CYS, ARG) And B (GLU and ASP). Is used for the treatment of Arthritis. * * formula