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Antianaphylactic and antibronchospastic N-benzhydryldiazacycloalkylalkananilides

机译:抗过敏和抗支气管痉挛的N-苯甲酰基二氮杂环烷基链烷胺

摘要

New piperazine derivatives of general formula: wherein:R is hydrogen or lower alkyl,A is straight or branched lower alkyl and R₁ and R₂ are respectively hydrogen, amino, alkylamino, dialkylamino mono or di(hydroxyalkyl)amino,morpholino, piperidino, N-alkylpiperazino, 1,3-dithiolan-2-ylidenamino, N-­alkylureido, isomers mixture thereof, individual enantiomers and pharmaceutically acceptable acid addition salts thereof. The new compounds exhibit a high antianaphylactic and antibronchospastic activity.
机译:通式的新哌嗪衍生物: <图像文件=“ IMGA0001.GIF” he =“ 37” imgContent =“ chem” imgFormat =“ GIF” wi =“ 107” /> ,其中:R是氢或低级烷基,A是直链或支链的低级烷基,R 1和R 2分别是氢,氨基,烷基氨基,二烷基氨基单或二(羟烷基)氨基,吗啉代,哌啶子基,N-烷基哌嗪子基,1,3-二硫杂环戊-2-基亚胺基氨基,N-烷基脲基,它们的异构体混合物,单个对映异构体及其药学上可接受的酸加成盐。新化合物具有很高的抗过敏和抗支气管痉挛活性。

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