1-(HYDROXYSTYRYL)-5H-2,3-BENZODIAZEPINE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME

摘要

This invention relates to new 1-(hydroxystyryl)-5H-2,3-benzodiazepine derivatives of the general formula (I) and to a process for the preparation thereof, furthermore to pharmaceutical compositions containing the same, IMAGE (I) wherein R stands for a hydrogen or halogen atom, or a C1-4 alkoxy group, R1 represents a hydrogen atom or a C1-4 alkyl group, R2 and R3 are identical and denote a C1-4 alkyl group, or combined they denote a methylene group. The compounds of the general formula (I) possess valuable positive inotropic (cardiotonic) potency, are capable to increase the myocardiac contractile force (heart performance in cardiac insufficiency), thus they can be applied in the therapy of chronic heart failure and coronary ailments.