MONOCLONAL ANTIBODIES AGAINST LENS EPITHELIAL CELLS AND¹METHODS FOR PREVENTING PROLIFERATION OF REMNANT LENS¹EPITHELIAL CELLS AFTER EXTRACAPSULAR EXTRACTION

摘要

Compositions and methods for their use are provided for preventing proliferation of remnant lens epithelial cells following extracapsular extraction. Complement-fixing monoclonal antibodies specific for lens epithelial cells are introduced into the anterior chamber of the eye. Following binding of the monoclonal antibody to any lens epithelial cells, complement is introduced into the anterior chamber effecting lysis of the remnant lens epithelial cells. The method may be used at the time of extracapsular cataract extraction or may be used subsequently to remove a second cataract resulting from proliferation of remnant lens epithelial cells.