Dibenzo-cycloheptenyl, -cycloheptyl and -oxepinyl amines having antihistaminic properties

摘要

There are provided compounds of formula I: CHEM wherein: X represents -CH2O-, -CH2CH2- or -CH=CH-; either A represents -OH and B represents hydrogen, or A and B taken together form a second bond between the carbons to which they are attached; either C represents hydrogen and D represents C1 to 6 alkyl, or C and D form a saturated two carbon chain. Y represents -CH2-, -C(=O)-, -CH(OH)-, -S-, -NH-, -0-, or -NHCH2CH2-; R represents C1 to 6 alkyl, -C(CH3)2CH2OH, -C(CH3)2CO2H, -C(CH3)2COOR min ; and may be at the 2, 3 or 4 position of the benzene ring relative to the rest of the molecule, R min represents C1 to 6 alkyl and n represents an integer between 3 and 6.